Adopted ORFans

ORF systematic name invesigator, institution ORF std name ORF Name description ORF Description Gene function summary ORF feature type
YBR056W Stephanie Schroeder Webster University Putative glycoside hydrolase of the mitochondrial intermembrane space Protein whose biological role is unknown; localizes to the mitochondrial intermembrane space Verified
YBR062C John Carmen
Northern Kentucky University
Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway Protein whose biological role and cellular location are unknown Uncharacterized
YBR078W David Markwardt Ohio Wesleyan University ECM33 ExtraCellular Mutant GPI-anchored protein of unknown function; possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p; ECM33 has a paralog, PST1, that arose from the whole genome duplication Verified
YBR094W Susan Parrish McDaniel College PBY1 P-BodY associated protein Putative tubulin tyrosine ligase associated with P-bodies; may have a role in mRNA metabolism; yeast knockout collection strain identified as a pby1 null mutant is actually wild-type for PBY1 and deleted for mms4 Component of the cytoplasmic mRNA processing body (P body); but not involved in mRNA catabolic process Verified
YCR043C Ellen France Georgia College Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene Protein whose biological role is unknown; localizes to the Golgi apparatus and the mating projection tip in large-scale studies Uncharacterized
YDL024C David Markwardt Ohio Wesleyan University DIA3 Digs Into Agar Protein of unknown function; involved in invasive and pseudohyphal growth Verified
YDL167C Susan Parrish McDaniel College NRP1 N (asparagine)-Rich Protein Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis Protein whose biological role is unknown; localizes to the cytoplasmic stress granule Verified
YDL199C Deborah Zies Univeristy of Mary Washington Putative transporter; member of the sugar porter family Uncharacterized
YDL218W David Markwardt Ohio Wesleyan Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin Predicted integral membrane protein whose biological role is unknown; localizes to the cytoplasm in a large-scale study Uncharacterized
YDR006C Jenny Lenkowski
Goucher College
SOK1 Suppressor Of Kinase Protein of unknown function; overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13 Verified
YDR132C Bernadette Connors Dominican College Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication Protein whose biological role is unknown; localizes to the mitochondrion, nucleus and cytoplasm in a large-scale study Verified
YDR210W David Markwardt Ohio Wesleyan Predicted tail-anchored plasma membrane protein; contains a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery Protein whose biological role and cellular location are unknown Uncharacterized
YDR532C purchased for Michael Wolyniak, Hampden-Syndey College, VA KRE28 Subunit of a kinetochore-microtubule binding complex; complex bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components; complex also includes Spc105p; modified by sumoylation Subunit of the condensed chromosome kinetochore whose biological role is unknown; localizes to the centromeric region of the chromosome; colocalizes with the spindle pole body in a large-scale study Verified
YEL007W Rhodes College MIT1 Muc1 expressed Independent of TEC1 Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1 Protein whose biological role is unknown; localizes to the nucleus and cytoplasm in a large scale study Verified
YEL037C Bernadette Connors Dominican College RAD23 RADiation sensitive Protein with ubiquitin-like N terminus; subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that binds damaged DNA; enhances protein deglycosylation activity of Png1p; also involved, with Rad4p, in ubiquitylated protein turnover; Rad4p-Rad23p heterodimer binds to promoters of DNA damage response genes to repress their transcription in the absence of DNA damage Verified
YER066W Jill Keeney, Juniata College RRT13 Regulator of rDNA Transcription Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription Protein whose biological role and cellular location are unknown Uncharacterized
YGL086W Michael Wolyniak, Hampden-Sydney College MAD1 Mitotic Arrest-Deficient Coiled-coil protein involved in spindle-assembly checkpoint; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon spindle assembly checkpoint arrest; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of anaphase promoting complex activity; forms a complex with Mad2p; gene dosage imbalance between MAD1 and MAD2 leads to chromosome instability A protein involved in activating mitotic spindle checkpoint assembly and negatively regulates protein import into the nucleus during this process; localizes to the kinetochore and nuclear pore Verified
YGL226W Gavin McStay
New York Institute of Technology
MTC3 Maintenance of Telomere Capping Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick with cdc13-1 Protein whose biological role is unknown; localizes to the mitochondrion in a large-scale study Verified
YGL247W Michael Wolyniak, Hampden-Sydney College BRR6 Bad Response to Refrigeration Essential nuclear envelope integral membrane protein; interacts and functions with Apq12p and Brl1p in lipid homeostasis; mutants are defective in nuclear pore complex biogenesis, nuclear envelope morphology, mRNA nuclear export, and are sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism; homologous to Brl1p Integral membrane protein of the nuclear envelope and ER; involved in lipid homeostasis; role in nuclear export of mRNA, and nuclear envelope organization Verified
YGR035C Stephanie Schroeder Webster University Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; YGR035C has a paralog, YLR346C, that arose from the whole genome duplication Protein whose biological role and cellular location are unknown Uncharacterized
YGR089W Joanna Haye/Shuba Ireland Xavier University of Louisiana NNF2 Protein that exhibits physical and genetic interactions with Rpb8p; Rpb8p is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation Predicted integral membrane protein whose biological role is unknown Verified
YGR161C Rhodes College RTS3 Putative component of the protein phosphatase type 2A complex Protein whose biological role is unknown; localizes to the nucleus and cytoplasm in a large-scale study Uncharacterized
YHL010C Jenny Lenkowski
Goucher College
ETP1 Ethanol Tolerance Protein Protein of unknown function required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences Verified
YHR022C Stephanie Schroeder Webster University Putative protein of unknown function; YHR022C is not an essential gene Protein whose biological role and cellular location are unknown Uncharacterized
YHR036W Michael Wolyniak, Hampden-Sydney College BRL1 BRr6 Like protein Essential nuclear envelope/ER integral membrane protein; interacts and functions with Apq12p and Brr6p in lipid homeostasis; mutants are defective in nuclear pore complex biogenesis, mRNA nuclear export and are sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents; identified as a dosage suppressor of a temperature sensitive mutation in the major karyopherin, CRM1; homologous to Brr6p Integral membrane protein of the nuclear envelope and ER; involved in lipid homeostasis; role in nuclear export of mRNA and protein, and nuclear envelope organization Verified
YHR087W Stephanie Schroeder Webster University RTC3 Restriction of Telomere Capping Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress Verified
YHR125W Stephanie Schroeder Webster University Putative protein of unknown function; conserved across S. cerevisiae strains Uncharacterized
YHR129C Bernadette Connors Dominican College ARP1 Actin-Related Protein Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; forms actin-like short filament composed of 9 or 10 Arp1p monomers; putative ortholog of mammalian centractin Verified
YIL040W Michael Wolyniak, Hampden-Sydney College APQ12 APical growth revealed by Quantitative morphological analysis Nuclear envelope/ER integral membrane protein; interacts and functions with Brr6p and Brl1p in lipid homeostasis; mutants are defective in nuclear pore complex biogenesis, nuclear envelope morphology, mRNA export from the nucleus and are sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism Integral membrane protein of the nuclear envelope and ER; involved in lipid homeostasis; role in nuclear export of mRNA, and nuclear envelope organization Verified
YIL089W David Aiello
Austin College
Protein of unknown function found in the ER and vacuole lumen; overexpression of YIL089W affects endocytic protein trafficking Protein whose biological role is unknown; localized to the vacuole lumen, endoplasmic reticulum; predicted to be an integral component of the membrane Verified
YIL105C Bernadette Connors Dominican College SLM1 Synthetic Lethal with Mss4 Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; TORC2 complex substrate and effector; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication Verified
YIL140W Dale Beach, Longwood University AXL2 AXiaL 2 bud site selection Integral plasma membrane protein; required for axial budding in haploid cells; localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate Verified
YIL156W Crystal Goldyn Mount Aloysius College UBP7 UBiquitin-specific Protease Ubiquitin-specific protease that cleaves ubiquitin-protein fusions; UBP7 has a paralog, UBP11, that arose from the whole genome duplication Verified
YIL158W Deborah Zies Univeristy of Mary Washington AIM20 Altered Inheritance rate of Mitochondria Protein of unknown function; overexpression causes cell cycle delay or arrest; green fluorescent protein (GFP)-fusion protein localizes to vacuole; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from nucleus to cytoplasm upon DNA replication stress; AIM20 has a paralog, SKG1, that arose from the whole genome duplication Protein whose biological role is unknown; localized to nucleus, cytoplasm, and vacuole Verified
YIR003W Indrani Bose Western Carolina Univeristy AIM21 Altered Inheritance rate of Mitochondria Subunit of a complex that associates with actin filaments; forms a complex with Tda2p that inhibits barbed end F-actin assembly; elevates actin monomer pools to increase endocytotic efficiency and to regulate the distribution of actin between cables and patches; Aim21p/Tda2p forms a larger complex with actin capping proteins Cap1p and Cap2p; involved in mitochondrial migration along actin filaments; recruited to cortical actin patches by SH3 domain-containing proteins Bbc1p and Abp1p Protein with a role in mitochondrial movement along actin filaments; localized to the actin cytoskeleton, shmoo tip, and ribosomes Verified
YJL030W Dale Beach, Longwood University MAD2 Mitotic Arrest-Deficient Component of the spindle-assembly checkpoint complex; delays onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p; regulates APC/C activity during prometaphase and metaphase of meiosis I; gene dosage imbalance between MAD1 and MAD2 leads to chromosome instability A subunit of the mitotic checkpoint complex; involved in mitotic spindle assembly checkpoint and chromosome decondensation; localizes to the condensed nuclear kinetochore and nuclear pore Verified
YJL107C Jenny Lenkowski
Goucher College
Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi Protein whose biological role and cellular location are unknown Uncharacterized
YJL171C David Markwardt Ohio Wesleyan University TOH1 TOS One Homolog GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress Protein whose biological role is unknown; localizes to the cell wall; localizes to mitochondrion and plasma membrane in different large-scale studies Verified
YJR118C John Carmen
Northern Kentucky University
ILM1 Increased Loss of Mitochondrial DNA Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth Verified
YJR126C Jenny Lenkowski
Goucher College
VPS70 Vacuolar Protein Sorting Protein of unknown function involved in vacuolar protein sorting; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum Endoplasmic reticulum protein involved in vacuolar protein sorting Verified
YKL023W Susan Parrish McDaniel College Putative protein of unknown function; predicted by computational methods to be involved in mRNA degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Protein whose biological role is unknown; localizes to the cytoplasm in a large-scale study Uncharacterized
YKL142W Rhodes College MRP8 Mitochondrial Ribosomal Protein Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; protein abundance increases in response to DNA replication stress; originally thought to be a mitochondrial ribosomal protein based on sequence analysis Protein whose biological role is unknown; localized to the cytoplasm Verified
YKL222C Rhodes College Protein of unknown function; may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine Verified
YKR095W Bernadette Connors Dominican College MLP1 Myosin-Like Protein Myosin-like protein associated with the nuclear envelope; nuclear basket protein that connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs; MLP1 has a paralog, MLP2, that arose from the whole genome duplication Verified
YKR098C Crystal Goldyn Mount Aloysius College UBP11 UBiquitin-specific Protease Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; UBP11 has a paralog, UBP7, that arose from the whole genome duplication Verified
YLL049W Dale Beach, Longwood University LDB18 Low Dye Binding Component of the dynactin complex; dynactin is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24 Verified
YLR001C Jill Keeney, Juniata College Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; predicted to be palmitoylated Protein whose biological role is unknown; localizes to the mitochondrion and the vacuolar membrane in large-scale studies Uncharacterized
YLR036C David Aiello
Austin College
Putative protein predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein Predicted integral membrane protein whose biological role is unknown Uncharacterized
YLR108C Bernadette Connors Dominican College Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene; protein abundance increases in response to DNA replication stress; YLR108C has a paralog, YDR132C, that arose from the whole genome duplication Protein whose biological role is unknown; localizes to the nucleus in a large-scale study Verified
YLR346C Stephanie Schroeder Webster University CIS1 CItrinin Sensitive knockout Protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; not an essential gene; YLR346C has a paralog, YGR035C, that arose from the whole genome duplication Protein whose biological role is unknown; localizes to the mitochondrion in a large-scale study Verified
YLR407W Joanna Haye/Shuba Ireland Xavier University of Louisiana Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus Protein whose biological role and cellular location are unknown Uncharacterized
YML018C Michael Wolyniak, Hampden-Sydney College Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; physical interaction with Atg27p suggests a possible role in autophagy; YML018C is not an essential gene; relative distribution to the vacuolar membrane decreases upon DNA replication stress; YML018C has a paralog, THI74, that arose from the whole genome duplication Protein whose biological role is unknown; localizes to the vacuole membrane in large scale studies Verified
YMR003W Indrani Bose Western Carolina Univeristy AIM34 Altered Inheritance rate of Mitochondria Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss Protein whose biological role and cellular location are unknown Verified
YMR107W Stephanie Schroeder Webster University SPG4 Stationary Phase Gene Protein required for high temperature survival during stationary phase; not required for growth on nonfermentable carbon sources Protein whose biological role and cellular location are unknown Verified
YMR295C Dale Beach, Longwood University Ilm1p BInding Protein of unknown function that associates with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud; not an essential gene; protein abundance increases in response to DNA replication stress; YMR295C has a paralog, YGR273C, that arose from the whole genome duplication Protein whose biological role is unknown; localizes to mating projection tip, buds, and colocalizes with ribosomes in multiple large-scale studies Verified
YMR316W John Carmen
Northern Kentucky University
DIA1 Digs Into Agar Protein of unknown function; involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Verified
YNL209W Bernadette Connors Dominican College SSB2 Stress-Seventy subfamily B Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication ATPase involved in protein folding, export of ribosomal subunit from nucleus, regulation of translation fidelity, rRNA processing; associated with polysomes and localized in the cytoplasm Verified
YNL213C Rhodes College RRG9 Required for Respiratory Growth Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Verified
YNL234W Jenny Lenkowski
Goucher College
Protein of unknown function with similarity to globins; has a functional heme-binding domain; mutant has aneuploidy tolerance; transcription induced by stress conditions; may be involved in glucose signaling or metabolism; regulated by Rgt1 Verified
YNL298W Bernadette Connors Dominican College CLA4 CLn Activity dependant Cdc42p-activated signal transducing kinase; member of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p; CLA4 has a paralog, SKM1, that arose from the whole genome duplication Serine/Threonine kinase; involved in septin ring organization, vacuole inheritance, regulation of exit from mitosis, positive regulation of protein import into nucleus; negative regulation of sterol import by negative regulation of transcription from RNA Pol II promoter; localizes to the vacuole, nucleus and bud Verified
YNL307C Dale Beach, Longwood University MCK1 Meiosis and Centromere regulatory Kinase Dual-specificity ser/thr and tyrosine protein kinase; roles in chromosome segregation, meiotic entry, genome stability, phosphorylation-dependent protein degradation (Rcn1p and Cdc6p), inhibition of protein kinase A, transcriptional regulation, inhibition of RNA pol III, calcium stress and inhibition of Clb2p-Cdc28p after nuclear division; MCK1 has a paralog, YGK3, that arose from the whole genome duplication Protein serine/threonine/tyrosine kinase involved in protein phosphorylation and breakdown; cyclin-binding protein; implicated in double-strand break repair via nonhomologous end joining, meiotic nuclear division, and mitotic chromosome segregation; involved in in ascospore formation and the cellular response to heat and salt stress Verified
YOL154W David Markwardt Ohio Wesleyan University ZPS1 Zinc- and pH-regulated Surface protein Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH Protein whose biological role is unknown; localizes to the cell wall in a classical study and to the vacuole in a large scale study Verified
YOR092W Jenny Lenkowski
Goucher College
ECM3 ExtraCellular Mutant Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication Verified
YOR324C Jenny Lenkowski
Goucher College
FRT1 Functionally Related to TCP1 Tail-anchored ER membrane protein of unknown function; substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly via a role in posttranslational translocation; FRT1 has a paralog, FRT2, that arose from the whole genome duplication Verified
YPL018W Bernadette Connors Dominican College CTF19 Chromosome Transmission Fidelity Outer kinetochore protein, needed for accurate chromosome segregation; component of kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as platform for kinetochore assembly; required for spindle assembly checkpoint; minimizes potentially deleterious centromere-proximal crossovers by preventing meiotic DNA break formation proximal to centromere; homolog of human centromere constitutive-associated network (CCAN) subunit CENP-P and fission yeast fta2 Verified
YPL031C Bernadette Connors Dominican College PHO85 PHOsphate metabolism Cyclin-dependent kinase; has ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle; human lissencephaly-associated homolog CDK5 functionally complements null mutation Cyclin-dependent protein serine/threonine kinase involved in regulation of phosphate and glycogen metabolism, cell cycle progression, establishment of cell polarity, autophagy, response to DNA damage, and calcium-mediated signaling; localized to the nucleus Verified
YPL055C Candice Jones Lane College LGE1 LarGE cells Protein of unknown function; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division Verified
YPL158C Dale Beach, Longwood University AIM44 Altered Inheritance rate of Mitochondria Protein that regulates Cdc42p and Rho1p; functions in the late steps of cytokinesis and cell separation; sustains Rho1p at the cell division site after actomyosin ring contraction; inhibits the activation of Cdc42-Cla4 at the cell division site to prevent budding inside the old bud neck; transcription is regulated by Swi5p; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from bud neck to cytoplasm upon DNA replication stress Protein with a role in assembly of the septum between dividing cells during cytokinesis; localized to the bud neck and bud tip Verified
YPL174C Dale Beach, Longwood University NIP100 Nuclear ImPort Large subunit of the dynactin complex; dynactin is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued) Verified
YPL257W Ellen France Georgia College Putative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene Predicted integral membrane protein whose biological role is unknown Uncharacterized
YPL269W Dale Beach, Longwood University KAR9 KARyogamy Spindle positioning factor; orients astral microtubules, connecting them to actin cables at the cortex with Bim1p and Myo2, resulting in proper spindle positioning; targeted for StuBL-dependent degradation at kinetochores by Slx5p-Slx8p, ensuring chromosome transmission fidelity and correct spindle positioning; role in karyogamy; localizes to the shmoo tip, the growing bud-tip, the nucleus, the kinetochore, the spindle and microtubules; homolog of adenomatous polyposis coli Verified
YPR149W Jenny Lenkowski
Goucher College
NCE102 NonClassical Export Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs); NCE102 has a paralog, FHN1, that arose from the whole genome duplication Verified