YeastORFan adopted ORFans (Table PDF)
| ORF systematic | Investigator | ORF Standard | ORF Name | ORF Description |
|---|---|---|---|---|
| YBR047W | Brian Schwartz, Columbus State University) | Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies | ||
| YBR056W | Stephanie Schroeder (Webster University) | Putative glycoside hydrolase of the mitochondrial intermembrane space | ||
| YBR062C | John Carmen (Northern Kentucky University) | Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway | ||
| YBR078W | David Markwardt (Ohio Wesleyan University) | ECM33 | ExtraCellular Mutant | GPI-anchored protein of unknown function; possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p; ECM33 has a paralog, PST1, that arose from the whole genome duplication |
| YBR094W | Susan Parrish (McDaniel College) | PBY1 | P-BodY associated protein | Putative tubulin tyrosine ligase associated with P-bodies; may have a role in mRNA metabolism; yeast knockout collection strain identified as a pby1 null mutant is actually wild-type for PBY1 and deleted for mms4 |
| YCR043C | Ellen France (Georgia College) | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene | ||
| YCR095C | David Kushner, Dickinson College | Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in their natural hosts | ||
| YCR102C | Aimee Miller, Millersville University and Brian Schwartz, Columbus State University | Putative protein of unknown function; involved in copper metabolism; similar to C. carbonum toxD gene; member of the quinone oxidoreductase family | ||
| YCR043C | Jayleen M. Diaz Mercado (Humacao Community College) | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus | ||
| YDL024C | David Markwardt (Ohio Wesleyan University) | DIA3 | Digs Into Agar | Protein of unknown function; involved in invasive and pseudohyphal growth |
| YDL167C | Susan Parrish (McDaniel College) | NRP1 | N (asparagine)-Rich Protein | Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis |
| YDL199C | Deborah Zies (University of Mary Washington) | Putative transporter; member of the sugar porter family | ||
| YDL199C | Vijaykumar Veerappan (Eastern Conneticut State University) | Putative transporter; member of the sugar porter family | ||
| YDL218W | David Markwardt (Ohio Wesleyan) | Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin | ||
| YDR006C | Jenny Lenkowski (Goucher College) | SOK1 | Suppressor of Kinase | Protein of unknown function; overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13 |
| YDR067C | David Kushner (Dickinson College) | Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT | ||
| YDR132C | Bernadette Connors (Dominican College) | Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication | ||
| YDR210W | David Markwardt (Ohio Wesleyan) | Predicted tail-anchored plasma membrane protein; contains a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery | ||
| YDR532C | Michael Wolyniak (Hampden-Sydney College) | KRE28 | Subunit of a kinetochore-microtubule binding complex; complex bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components; complex also includes Spc105p; modified by sumoylation | |
| YEL007W | Rhodes College | MIT1 | Muc1 expressed Independent of TEC1 | Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1 |
| YEL037C | Bernadette Connors (Dominican College) | RAD23 | RADiation sensitive | Protein with ubiquitin-like N terminus; subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that binds damaged DNA; enhances protein deglycosylation activity of Png1p; also involved, with Rad4p, in ubiquitylated protein turnover; Rad4p-Rad23p heterodimer binds to promoters of DNA damage response genes to repress their transcription in the absence of DNA damage |
| YER066W | Jill Keeney (Juniata College) | RRT13 | Regulator of rDNA Transcription | Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription |
| YER156C | Brian Schwartz (Columbus State University) | Putative protein of unknown function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor; similarity to mammalian MYG1 | ||
| YFR012W | Jill Keeney (Juniata College) | Protein of unknown function; deletion mutant shows strong genetic interaction with cdc28-as1 mutant in the presence of 1-NM-PP1; DCV1 has a paralog, YOL019W, that arose from the whole genome duplication | ||
| YGL086W | Michael Wolyniak (Hampden-Sydney College) | MAD1 | Mitotic-Arrest Deficient | Coiled-coil protein involved in spindle-assembly checkpoint; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon spindle assembly checkpoint arrest; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of anaphase promoting complex activity; forms a complex with Mad2p; gene dosage imbalance between MAD1 and MAD2 leads to chromosome instability |
| YGL226W | Gavin McStay (New York Institute of Technology) | MTC3 | Maintenance of Telomere Capping | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick with cdc13-1 |
| YGL247W | Michael Wolyniak (Hampden-Sydney College) | BRR6 | Bad Response to Refrigeration | Essential nuclear envelope integral membrane protein; interacts and functions with Apq12p and Brl1p in lipid homeostasis; mutants are defective in nuclear pore complex biogenesis, nuclear envelope morphology, mRNA nuclear export, and are sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism; homologous to Brl1p |
| YGR035C | Stephanie Schroeder (Webster University) | Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; YGR035C has a paralog, YLR346C, that arose from the whole genome duplication | ||
| YGR089W | Joanna Haye / Shuba Ireland Xavier (University of Louisiana) | NNF2 | Protein that exhibits physical and genetic interactions with Rpb8p; Rpb8p is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation | |
| YGR161C | Rhodes College | RTS3 | Putative component of the protein phosphatase type 2A complex | |
| YHL010C | Jenny Lenkowski (Goucher College) | ETP1 | Ethanol Tolerance Protein | Protein of unknown function required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences |
| YHL010C | Vijaykumar Veerappan (Eastern Conneticut State University) | Protein of unknown function required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences | ||
| YHR022C | Stephanie Schroeder (Webster University) | Putative protein of unknown function; YHR022C is not an essential gene | ||
| YHR033W | Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YHR033W has a paralog, PRO1, that arose from the whole genome duplication | |||
| YHR036W | Michael Wolyniak (Hampden-Sydney College) | BRL1 | BRr6 Like protein | Essential nuclear envelope/ER integral membrane protein; interacts and functions with Apq12p and Brr6p in lipid homeostasis; mutants are defective in nuclear pore complex biogenesis, mRNA nuclear export and are sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents; identified as a dosage suppressor of a temperature sensitive mutation in the major karyopherin, CRM1; homologous to Brr6p |
| YHR045W | Aimee Miller (Millersville University) | Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum | ||
| YHR087W | Stephanie Schroeder (Webster University) | RTC3 | Restriction of Telomere Capping | Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress |
| YHR125W | Stephanie Schroeder (Webster University) | Putative protein of unknown function; conserved across S. cerevisiae strains | ||
| YHR129C | Bernadette Connors (Dominican College) | ARP1 | Actin-Related Protein | Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; forms actin-like short filament composed of 9 or 10 Arp1p monomers; putative ortholog of mammalian centractin |
| YIL040W | Michael Wolniak (Hampden-Sydney College) | APQ12 | APical growth revealed by Quantitative morphological analysis | Nuclear envelope/ER integral membrane protein; interacts and functions with Brr6p and Brl1p in lipid homeostasis; mutants are defective in nuclear pore complex biogenesis, nuclear envelope morphology, mRNA export from the nucleus and are sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism |
| YIL066C | For the green screen assay | Minor isoform of large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits; RNR3 has a paralog, RNR1, that arose from the whole genome duplication | ||
| YIL089W | David Aiello (Austin College) | Protein of unknown function found in the ER and vacuole lumen; overexpression of YIL089W affects endocytic protein trafficking | ||
| YIL105C | Bernadette Connors (Dominican College) | SLM1 | Synthetic Lethal with Mss4 | Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; TORC2 complex substrate and effector; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication |
| YIL140W | Dale Beach (Longwood University) | AXL2 | AXial 2 bud site selection | Integral plasma membrane protein; required for axial budding in haploid cells; localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate |
| YIL156W | Crystal Goldyn (Mount Aloysius College) | UBP7 | UBiquitin-specific Protease | Ubiquitin-specific protease that cleaves ubiquitin-protein fusions; UBP7 has a paralog, UBP11, that arose from the whole genome duplication |
| YIL158W | Deborah Zies (University of Mary Washington) | AIM20 | Altered Inheritance rate of Mitochondria | Protein of unknown function; overexpression causes cell cycle delay or arrest; green fluorescent protein (GFP)-fusion protein localizes to vacuole; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from nucleus to cytoplasm upon DNA replication stress; AIM20 has a paralog, SKG1, that arose from the whole genome duplication |
| YIR003W | Indrani Bose Western (Carolina University) | AIM21 | Altered Inheritance rate of Mitochondria | Subunit of a complex that associates with actin filaments; forms a complex with Tda2p that inhibits barbed end F-actin assembly; elevates actin monomer pools to increase endocytotic efficiency and to regulate the distribution of actin between cables and patches; Aim21p/Tda2p forms a larger complex with actin capping proteins Cap1p and Cap2p; involved in mitochondrial migration along actin filaments; recruited to cortical actin patches by SH3 domain-containing proteins Bbc1p and Abp1p |
| YIR030C | Bill Alexander (Truman State University) | Protein of unknown function; expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain | ||
| YJL030W | Dale Beach, Longwood University | MAD2 | Miotic Arrest-Deficient | Component of the spindle-assembly checkpoint complex; delays onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p; regulates APC/C activity during prometaphase and metaphase of meiosis I; gene dosage imbalance between MAD1 and MAD2 leads to chromosome instability |
| YJL107C | Jenny Lenkowski (Goucher College) | Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi | ||
| YJL171C | David Markwardt (Ohio Wesleyan University) | TOH1 | TOS One Homolog | GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress |
| YJR118C | John Carmen (Northern Kentucky University) | ILM1 | Increased Loss of Mitochondrial DNA | Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth |
| YJR126C | Jenny Lenkowski (Goucher College) | VPS70 | Vacuolar Protein Sorting | Protein of unknown function involved in vacuolar protein sorting; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum |
| YKL023W | Susan Parrish McDaniel College | Putative protein of unknown function; predicted by computational methods to be involved in mRNA degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm | ||
| YKL142W | Rhodes College | MRP8 | Mitochondrial Ribosomal Protein | Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; protein abundance increases in response to DNA replication stress; originally thought to be a mitochondrial ribosomal protein based on sequence analysis |
| YKL222C | Rhodes College | Protein of unknown function; may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine | ||
| YKR004C | Michael Wolyniak (Hampden-Syndey College) | ExtraCellular Mutant | Non-essential protein of unknown function | |
| YKR049C | Michael Parra (Susquehanna University) | Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies | ||
| YKR095W | Bernadette Connors (Dominican College) | MLP1 | Myosin-Like Protein | Myosin-like protein associated with the nuclear envelope; nuclear basket protein that connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs; MLP1 has a paralog, MLP2, that arose from the whole genome duplication |
| YKR098C | Crystal Goldyn (Mount Aloysius College) | UBP11 | UBiquitin-specific Protease | Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; UBP11 has a paralog, UBP7, that arose from the whole genome duplication |
| YLL049W | Dale Beach (Longwood University) | LDB18 | Low Dye Binding | Component of the dynactin complex; dynactin is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24 |
| YLR001C | Jill Keeney (Juniata College) | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; predicted to be palmitoylated | ||
| YLR036C | David Aiello (Austin College) | Putative protein predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein | ||
| YLR064W | Jill Keeney (Juniata College) | MAT alpha version of PER33 | Protein that localizes to the endoplasmic reticulum; also associates with the nuclear pore complex; deletion extends chronological lifespan; highly conserved across species, orthologous to human TMEM33 and paralogous to Pom33p; protein abundance increases in response to DNA replication stress | |
| YLR108C | Bernadette Connors (Dominican College) | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene; protein abundance increases in response to DNA replication stress; YLR108C has a paralog, YDR132C, that arose from the whole genome duplication | ||
| YLR126C | Aimee Miller (Millersville University) | Putative glutamine amidotransferase; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress | ||
| YLR267W | Michael Wolyniak (Hampden-Syndey College) | BOP2 | Bypass Of Pam1 | Protein of unknown function |
| YLR346C | Stephanie Schroeder (Webster University) | CIS1 | CItrinin Sensitive knockout | Protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; not an essential gene; YLR346C has a paralog, YGR035C, that arose from the whole genome duplication | YLR407W | Joanna Haye / Shuba Ireland Xavier (University of Louisiana) | Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus |
| YML018C | Michael Wolyniak (Hampden-Sydney College) | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; physical interaction with Atg27p suggests a possible role in autophagy; YML018C is not an essential gene; relative distribution to the vacuolar membrane decreases upon DNA replication stress; YML018C has a paralog, THI74, that arose from the whole genome duplication | ||
| YMR003W | Indrani Bose (Western Carolina University) | AIM34 | Altered Inheritance rate of Mitochondria | Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss |
| YMR107W | Stephanie Schroeder (Webster University) | SPG4 | Stationary Phase Gene | Protein required for high temperature survival during stationary phase; not required for growth on nonfermentable carbon sources |
| YMR295C | Dale Beach (Longwood University) | IIm1p BInding | Protein of unknown function that associates with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud; not an essential gene; protein abundance increases in response to DNA replication stress; YMR295C has a paralog, YGR273C, that arose from the whole genome duplication | |
| YMR316W | John Carmen (Northern Kentucky University) | DIA1 | Digs Into Agar | Protein of unknown function; involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern |
| YNL056W | David Kushner (Dickinson College) | OCA2 | Oxidant-induced Cell cycle Arrest | Protein of unknown function; similar to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene |
| YNL209W | Bernadette Connors (Dominican College) | SSB2 | Stress-Seventy subfamily B | Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication |
| YNL213C | Rhodes College | RRG9 | Required for Respiratory Growth | Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
| YNL234W | Jenny Lenkowski (Goucher College) | Protein of unknown function with similarity to globins; has a functional heme-binding domain; mutant has aneuploidy tolerance; transcription induced by stress conditions; may be involved in glucose signaling or metabolism; regulated by Rgt1 | ||
| YNL298W | Bernadette Connors (Dominican College) | CLA4 | CLn Activity dependent | Cdc42p-activated signal transducing kinase; member of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p; CLA4 has a paralog, SKM1, that arose from the whole genome duplication |
| YNL307C | Dale Beach (Longwood University) | MCK1 | Meiosis and Centromere regulatory Kinase | Dual-specificity ser/thr and tyrosine protein kinase; roles in chromosome segregation, meiotic entry, genome stability, phosphorylation-dependent protein degradation (Rcn1p and Cdc6p), inhibition of protein kinase A, transcriptional regulation, inhibition of RNA pol III, calcium stress and inhibition of Clb2p-Cdc28p after nuclear division; MCK1 has a paralog, YGK3, that arose from the whole genome duplication |
| YOL154W | David Markwardt (Ohio Wesleyan University) | ZPS1 | Zinc- and pH- regulated Surface protein | Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH |
| YOR092W | Jenny Lenkowski (Goucher College) | ECM3 | ExtraCellular Mutant | Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication |
| YOR296W | Brian Schwartz (Columbus State University) | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene | ||
| YOR324C | Jenny Lenkowski (Goucher College) | FRT1 | Functionally Related to TCP1 | Tail-anchored ER membrane protein of unknown function; substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly via a role in posttranslational translocation; FRT1 has a paralog, FRT2, that arose from the whole genome duplication |
| YOR355W | Michael Wolyniak (Hampden-Syndey College) | GDS1 | Protein of unknown function; required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies | |
| YPL018W | Bernadette Connors (Dominican College) | CTF19 | Chromosome Transmission Fidelity | Outer kinetochore protein, needed for accurate chromosome segregation; component of kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as platform for kinetochore assembly; required for spindle assembly checkpoint; minimizes potentially deleterious centromere-proximal crossovers by preventing meiotic DNA break formation proximal to centromere; homolog of human centromere constitutive-associated network (CCAN) subunit CENP-P and fission yeast fta2 |
| YPL031C | Bernadette Connors (Dominican College) | PHO85 | PHOsphate metabolism | Cyclin-dependent kinase; has ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle; human lissencephaly-associated homolog CDK5 functionally complements null mutation |
| YPL055C | Candice Jones (Lane College) | LGE1 | LarGE cells | Protein of unknown function; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division |
| YPL158C | Dale Beach (Longwood University) | AIM44 | Altered Inheritance rate of Mitochondria | Protein that regulates Cdc42p and Rho1p; functions in the late steps of cytokinesis and cell separation; sustains Rho1p at the cell division site after actomyosin ring contraction; inhibits the activation of Cdc42-Cla4 at the cell division site to prevent budding inside the old bud neck; transcription is regulated by Swi5p; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from bud neck to cytoplasm upon DNA replication stress |
| YPL174C | Dale Beach (Longwood University) | NIP100 | Nuclear ImPort | Large subunit of the dynactin complex; dynactin is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued) |
| YPL225W | Jill Keeney (Juniata College) | Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress | ||
| YPL257W | Ellen France (Georgia College) | Putative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene | ||
| YPL263C | Michael Wolyniak (Hampden-Syndey College) | KEL3 | KELch | Cytoplasmic protein of unknown function |
| YPL269W | Dale Beach (Longwood University) | KAR9 | KARyogamy | Spindle positioning factor; orients astral microtubules, connecting them to actin cables at the cortex with Bim1p and Myo2, resulting in proper spindle positioning; targeted for StuBL-dependent degradation at kinetochores by Slx5p-Slx8p, ensuring chromosome transmission fidelity and correct spindle positioning; role in karyogamy; localizes to the shmoo tip, the growing bud-tip, the nucleus, the kinetochore, the spindle and microtubules; homolog of adenomatous polyposis coli |
| YPR149W | Jenny Lenkowski (Goucher College) | NCE102 | NonClassical Export | Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs); NCE102 has a paralog, FHN1, that arose from the whole genome duplication |
| YHR045W | Aimee Miller (Millersville University) | Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum | ||
| YPL247C | Steve Johnston (North Central College) | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest | ||
| YPR153W | Michael Wolyniak (Hampden-Syndey College) | Protein of unknown function |